HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 779
+	Hs
		1068666 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		234236 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		728515 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		725019 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		502926 MYH3_HUMAN (4-887): 4.28e-29: 129: 9.04		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1045520 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1061248 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1059270 GOGB1_HUMAN (1144-1736): 3.26e-14: 81: 12.80		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		724876 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		1313532 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1068669 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		724884 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		724864 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		724873 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Mm
		561168 SPTN1_MOUSE (4-1212): 2.57e-19: 97.6: 10.27		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Mm
		82769 B9EKJ1_MOUSE (4-1212): 8.41e-19: 96.1: 10.31		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		724914 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		RHG24_HUMAN (55-181): 6.43e-27: 119: 25.93
+	Hs
		1045526 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		725013 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21
+	Hs
		108759 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		H0Y2S9_HUMAN (283-484): 4.95e-16: 85: 17.96