HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: WRP73 (Q9P2S5)
WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)
Gene: WRAP73

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1756 Hs			1 460
+	Hs
		234241 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		WDR5B_HUMAN (270-456): 2.27e-41: 151: 15.51
+	Hs
		728524 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		WRP73_HUMAN (1-460): 4.09e-100: 308: 100.00
+	Hs
		1061277 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		WRP73_HUMAN (1-460): 4.09e-100: 308: 100.00
+	Hs
		551863 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WRP73_HUMAN (1-460): 4.09e-100: 308: 100.00
+	Hs
		903240 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		1061204 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		SNR40_HUMAN (170-459): 4.37e-59: 199: 11.07
+	Hs
		197084 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		PRP4_HUMAN (50-360): 9.05e-22: 99: 13.75
+	Hs
		792973 CENPE_HUMAN (723-1718): 1.85e-27: 124: 11.52		LIS1_HUMAN (275-459): 3.43e-39: 147: 9.73
+	Hs
		903212 SPTN1_HUMAN (4-1191): 1.92e-18: 94.9: 10.52		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		903233 GOGB1_HUMAN (1144-1736): 3.26e-14: 81: 12.80		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		551655 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		903607 MACF1_HUMAN (498-1680): 1.71e-12: 75.4: 12.90		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		903399 MY18A_HUMAN (485-984): 1.11e-10: 69.2: 12.86		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		551766 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		WDR5B_HUMAN (270-456): 2.27e-41: 151: 15.51
+	Hs
		903137 SPTB2_HUMAN (559-1683): 4.02e-10: 67.6: 11.36		WDR5_HUMAN (270-456): 8.41e-45: 161: 16.04
+	Hs
		551632 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		LIS1_HUMAN (275-459): 3.43e-39: 147: 9.73
+	Hs
		728492 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		POC1A_HUMAN (1-76): 5.81e-12: 69: 15.39
+	Hs
		1061226 NUMA1_HUMAN (2-783): 1.46e-15: 85.3: 10.87		KTNB1_HUMAN (8-171): 3.12e-13: 73.7: 18.08
+	Hs
		551854 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		NLE1_HUMAN (1-76): 3.09e-15: 79.8: 17.95
+	Hs
		1313659 MACF1_HUMAN (498-1680): 1.71e-12: 75.4: 12.90		KTNB1_HUMAN (8-171): 3.12e-13: 73.7: 18.08