HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: MTUS1 (Q9ULD2)
Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)
Gene: MTUS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 1270
+	Hs
		1068662 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		SLK_HUMAN (732-1267): 1.26e-33: 143: 16.64
+	Hs
		1068617 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		MY18A_HUMAN (732-1270): 2.93e-31: 136: 12.43
+	Hs
		1068536 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		PLEC_HUMAN (447-1270): 1.04e-26: 121: 9.29
+	Hs
		63151 MYH2_HUMAN (1-850): 2.72e-29: 130: 9.21		CCD69_HUMAN (1006-1241): 1.15e-41: 157: 28.03
+	Hs
		528356 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH6_HUMAN (441-1247): 1.72e-27: 123: 9.91
+	Hs
		724943 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MY18A_HUMAN (732-1270): 2.93e-31: 136: 12.43
+	Hs
		148769 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		CTRO_HUMAN (446-1039): 1.02e-20: 101: 8.65
+	Hs
		148841 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		CTRO_HUMAN (446-1039): 1.02e-20: 101: 8.65
+	Mm
		93578 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		DESP_MOUSE (454-1267): 2.75e-28: 126: 8.47
+	Hs
		1034604 GOGA4_HUMAN (2-1336): 6.16e-43: 175: 9.40		CIP2A_HUMAN (844-1239): 2.01e-12: 74.1: 20.43
+	Hs
		148466 MYH11_HUMAN (1-836): 1.44e-34: 147: 9.73		CTRO_HUMAN (446-1039): 1.02e-20: 101: 8.65
+	Rn
		361106 MYH6_RAT (1-860): 1.23e-29: 131: 8.60		MYH6_RAT (497-1216): 1.39e-24: 114: 9.77
+	Hs
		502901 MYH6_HUMAN (1-1003): 1.54e-38: 160: 9.09		MYH3_HUMAN (823-1270): 1.42e-15: 84.8: 12.88
+	Hs
		724994 CP250_HUMAN (1-1328): 4.6e-43: 175: 11.06		MYH9_HUMAN (980-1268): 1.48e-10: 68.3: 14.88
+	Hs
		148460 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		CTRO_HUMAN (446-1039): 1.02e-20: 101: 8.65
+	Hs
		724839 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		MYH9_HUMAN (980-1268): 1.48e-10: 68.3: 14.88
+	Hs
		502933 MYH3_HUMAN (4-887): 4.28e-29: 129: 9.04		MYH4_HUMAN (458-1014): 1.85e-17: 91: 8.23
+	Hs
		724686 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		MYH9_HUMAN (980-1268): 1.48e-10: 68.3: 14.88