HitPredict

Interactor 1: ZIC3 (O60481)
Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3)
Gene: ZIC3

Interactor 2: RNF4 (P78317)
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)
Gene: RNF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29180619
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 467 Hs			1 190
+	Hs
		941453 ZN160_HUMAN (1-359): 1.42e-122: 378: 14.25		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941023 ZN658_HUMAN (8-465): 3.23e-116: 367: 14.34		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		549149 ZN250_HUMAN (214-464): 7.52e-90: 286: 22.22		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941352 ZN184_HUMAN (5-256): 1.78e-83: 274: 8.94		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		940950 ZKSC8_HUMAN (213-464): 4.5e-82: 266: 22.56		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941120 ZN227_HUMAN (179-465): 6.29e-80: 265: 18.51		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941165 ZN283_HUMAN (5-272): 3.93e-80: 263: 8.14		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941450 Z286A_HUMAN (201-448): 4.87e-78: 254: 25.40		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941407 ZN436_HUMAN (241-464): 2.65e-74: 243: 26.47		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		941201 ZN420_HUMAN (3-160): 2.83e-40: 155: 6.33		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		1244152 ZN397_HUMAN (251-464): 1.99e-81: 263: 23.68		COP1_HUMAN (125-189): 3.88e-12: 65.8: 32.31
+	Hs
		485115 GLI3_HUMAN (266-439): 8.6e-38: 149: 47.19		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		485056 GLI2_HUMAN (250-408): 7.2e-37: 146: 51.24		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		563297 ZNF16_HUMAN (4-143): 9.06e-37: 145: 4.29		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		856011 ZN143_HUMAN (322-429): 2.72e-18: 89.7: 37.27		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		563463 ZNF22_HUMAN (301-387): 8.81e-16: 78.2: 45.98		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		563248 ZNF12_HUMAN (27-100): 4.17e-13: 73.4: 8.11		RNF4_HUMAN (1-190): 9.49e-57: 179: 100.00
+	Hs
		485077 GLI2_HUMAN (250-408): 7.2e-37: 146: 51.24		COP1_HUMAN (125-189): 3.88e-12: 65.8: 32.31
+	Hs
		1089375 ZN426_HUMAN (301-410): 7.04e-14: 75.9: 34.78		LONF1_HUMAN (15-189): 7.63e-31: 119: 18.08