HitPredict

Interactor 1: PLXC1 (O60486)
Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232)
Gene: PLXNC1

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Plexin_cytopl~Ras, Plexin_RBD~Ras, Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1568 Hs			1 189
+	Hs
		349072 MET_HUMAN (35-928): 8.43e-162: 529: 13.07		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349813 MET_HUMAN (35-928): 8.43e-162: 529: 13.07		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349716 PLXA1_HUMAN (24-941): 8.21e-128: 442: 15.89		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348992 PLXA1_HUMAN (24-941): 8.21e-128: 442: 15.89		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070445 PLXA1_HUMAN (24-941): 8.21e-128: 442: 15.89		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		253442 PLXA2_HUMAN (6-929): 1.77e-120: 420: 15.02		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		350661 PLXA1_HUMAN (24-941): 8.21e-128: 442: 15.89		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		349625 SEM4C_HUMAN (28-605): 7.54e-124: 410: 14.09		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		348909 SEM4C_HUMAN (28-605): 7.54e-124: 410: 14.09		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		1070385 SEM4C_HUMAN (28-605): 7.54e-124: 410: 14.09		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		253443 PLXA2_HUMAN (6-929): 1.77e-120: 420: 15.02		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		165201 PLXB2_HUMAN (33-931): 1.68e-112: 396: 17.47		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		350524 SEM4C_HUMAN (28-605): 7.54e-124: 410: 14.09		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		914341 SEM4C_HUMAN (28-605): 7.54e-124: 410: 14.09		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		165135 PLXB2_HUMAN (33-931): 1.68e-112: 396: 17.47		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		165181 PLXB2_HUMAN (33-931): 1.68e-112: 396: 17.47		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Mm
		914512 SEM4A_MOUSE (18-551): 7.43e-76: 271: 13.74		RB11A_MOUSE (4-184): 2.43e-72: 219: 33.88
+	Hs
		195964 PLXB1_HUMAN (530-869): 5.08e-24: 112: 14.16		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Dm
		381633 Q0KIF1_DROME (371-934): 2.35e-43: 176: 17.53		RAS2_DROME (1-189): 2.25e-55: 175: 54.92