HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	15831486, 9478921
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1130
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (1-1130): 0: 984: 100.00
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (1-1130): 0: 901: 85.00
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (1-1130): 0: 901: 85.00
+	Hs
		235040 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		235036 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		235037 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		YES_HUMAN (5-510): 3.73e-179: 537: 39.42
+	Hs
		235035 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		LCK_HUMAN (9-508): 3.02e-177: 531: 38.49
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (13-510): 0: 545: 38.19
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (9-508): 4.68e-172: 517: 35.77
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (27-500): 3.23e-155: 474: 36.27
+	Hs
		235051 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		CSK_HUMAN (61-500): 1.81e-155: 472: 37.72
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (13-510): 0: 547: 38.58
+	Mm
		250951 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		CSK_MOUSE (61-500): 2.58e-155: 472: 37.95
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (5-510): 3.73e-179: 537: 39.42
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (2-509): 5.33e-178: 533: 38.88
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (9-508): 5.18e-175: 526: 38.79
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (9-508): 4.68e-172: 517: 35.77
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (9-508): 9.12e-173: 519: 36.15
+	Mm
		782845 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		CSK_MOUSE (61-500): 2.58e-155: 472: 37.95
+	Mm
		623689 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		TEC_MOUSE (65-498): 3.48e-100: 332: 40.18