HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10508618
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction GO:0007166 - cell surface receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1210
+	Mm
		250953 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		EGFR_MOUSE (1-1210): 0: 1258: 90.35
+	Hs
		338891 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338574 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338618 DOK3_HUMAN (3-395): 1.57e-94: 294: 36.74		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		151678 IRS4_HUMAN (1-387): 4.11e-85: 284: 17.17		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338739 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383949 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383858 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		151685 IRS4_HUMAN (1-387): 4.11e-85: 284: 17.17		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383894 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		235038 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		434273 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		434219 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Mm
		546269 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65
+	Hs
		434248 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		411486 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Mm
		546280 DOK3_MOUSE (3-395): 1.39e-99: 305: 33.50		INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65
+	Mm
		956526 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64
+	Mm
		815727 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		KSYK_MOUSE (718-961): 3.5e-53: 199: 42.04
+	Hs
		789086 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37