HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25814554, 15831486, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 509
+	Hs
		235036 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		235040 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		235037 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		YES_HUMAN (26-507): 0: 581: 58.06
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (1-509): 0: 585: 62.33
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (28-507): 0: 583: 57.05
+	Hs
		235031 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (1-509): 0: 602: 65.04
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (1-509): 0: 585: 62.33
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (20-507): 0: 586: 55.00
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (49-502): 5.34e-171: 513: 42.21
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (1-507): 0: 579: 52.76
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (61-500): 3.54e-162: 471: 37.64
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (49-502): 5.34e-171: 513: 42.21
+	Hs
		996570 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ITK_HUMAN (7-500): 1.08e-177: 515: 33.33
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21
+	Hs
		789086 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95
+	Mm
		623689 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		TEC_MOUSE (7-503): 8.14e-166: 485: 33.59
+	Hs
		789005 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		TEC_HUMAN (7-503): 2.17e-169: 494: 32.56