HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11470823
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 1114
+	Hs
		434273 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		434219 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		434248 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		RET_HUMAN (1-1114): 0: 1295: 100.00
+	Hs
		235032 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Mm
		250953 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83
+	Hs
		338891 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383949 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		338574 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		383858 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		338618 DOK3_HUMAN (3-395): 1.57e-94: 294: 36.74		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Mm
		1101896 DOK6_MOUSE (3-330): 6.35e-106: 317: 20.88		NTRK3_MOUSE (464-1018): 4.58e-135: 431: 24.46
+	Hs
		151678 IRS4_HUMAN (1-387): 4.11e-85: 284: 17.17		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		338739 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		151685 IRS4_HUMAN (1-387): 4.11e-85: 284: 17.17		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		383894 DOK4_HUMAN (3-335): 6.54e-93: 284: 20.11		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		339065 DOK5_HUMAN (3-282): 9.87e-92: 280: 21.23		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Hs
		151711 IRS4_HUMAN (1-387): 4.11e-85: 284: 17.17		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		1081513 DOK6_HUMAN (3-330): 2.1e-105: 316: 20.59		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Mm
		452182 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		CSF1R_MOUSE (706-1014): 1.89e-73: 265: 40.90
+	Hs
		499285 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		KIT_HUMAN (702-1024): 6.85e-74: 266: 39.31