HitPredict

Interactor 1: STX10 (O60499)
Syntaxin-10 (Syn10)
Gene: STX10

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 249 Hs			1 116
+	Hs
		235129 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		235130 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		212700 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Hs
		235174 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Rn
		1144363 STX6_RAT (1-234): 2.54e-61: 195: 61.67		VAMP1_RAT (2-78): 9.26e-27: 97.3: 37.66
+	Rn
		1144365 STX6_RAT (1-234): 2.54e-61: 195: 61.67		VAMP8_RAT (2-69): 7.27e-25: 91.9: 27.94
+	Hs
		212772 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Hs
		212689 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		212988 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP8_HUMAN (2-74): 9.04e-26: 94.2: 26.03
+	Hs
		212790 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		212690 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		212844 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Dm
		577224 Q7JRF1_DROME (1-249): 1.2e-51: 172: 31.23		SYB_DROME (2-88): 9.74e-30: 105: 39.08
+	Hs
		306889 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Hs
		850607 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Hs
		261740 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		926267 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		263392 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		1079469 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Hs
		87583 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		C9JXZ5_HUMAN (20-73): 3.33e-19: 76.9: 29.63