HitPredict

Interactor 1: STX10 (O60499)
Syntaxin-10 (Syn10)
Gene: STX10

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	30833792, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~SNARE
Common GO terms	GO:0000149 - SNARE binding GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0019905 - syntaxin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 249 Hs			1 295
+	Hs
		212779 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		212995 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		873597 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Zm
		39691 A0A1D6N0J7_MAIZE (2-248): 1.33e-59: 191: 23.16		A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80
+	Dm
		1095557 Q5BI25_DROME (13-249): 1.44e-43: 152: 29.28		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		169421 BET1_HUMAN (133-249): 2.91e-31: 113: 14.53		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		169605 BET1_HUMAN (133-249): 2.91e-31: 113: 14.53		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Dm
		1095586 Q9VV76_DROME (5-235): 9.81e-35: 126: 14.72		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		235208 STX10_HUMAN (1-233): 1.52e-69: 215: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1095587 Q9VVX6_DROME (141-249): 3.83e-25: 97.6: 18.35		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		212982 STX6_HUMAN (1-233): 6.56e-59: 188: 61.09		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Sc
		696591 TLG1_YEAST (2-232): 9.05e-31: 115: 19.05		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Sc
		611768 BET1_YEAST (108-245): 1.12e-24: 97.2: 16.31		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Sc
		696560 VAM7_YEAST (63-223): 3.59e-21: 91.8: 16.77		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		1306217 STX8_HUMAN (3-230): 5.49e-38: 134: 16.52		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Hs
		169588 BET1_HUMAN (133-249): 2.91e-31: 113: 14.53		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1353750 Q9VV76_DROME (5-235): 9.81e-35: 126: 14.72		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366628 Q9VV76_DROME (5-235): 9.81e-35: 126: 14.72		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1353751 Q9VVX6_DROME (141-249): 3.83e-25: 97.6: 18.35		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366629 Q9VVX6_DROME (141-249): 3.83e-25: 97.6: 18.35		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53