HitPredict

Interactor 1: NPHN (O60500)
Nephrin (Renal glomerulus-specific cell adhesion receptor)
Gene: NPHS1

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	12846735, 12668668, 15634346
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0010467 - gene expression
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1241 Hs			1 537
+	Hs
		297881 NFASC_HUMAN (1-740): 1.41e-43: 175: 9.78		FYN_HUMAN (1-537): 0: 643: 100.00
+	Hs
		235232 NPHN_HUMAN (1-260): 1.46e-23: 110: 12.88		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		523211 TUTLB_HUMAN (520-1036): 2.89e-18: 93.2: 26.47		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		433507 TUTLB_HUMAN (520-1036): 2.89e-18: 93.2: 26.47		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		297880 NFASC_HUMAN (1-740): 1.41e-43: 175: 9.78		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Hs
		434111 ROBO1_HUMAN (4-328): 4.43e-26: 118: 16.11		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		434019 ROBO2_HUMAN (1-284): 3.55e-20: 99.4: 15.28		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		434081 TUTLB_HUMAN (520-1036): 2.89e-18: 93.2: 26.47		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		433947 KIRR1_HUMAN (450-935): 6.55e-15: 82: 23.05		LYN_HUMAN (1-535): 0: 535: 54.48
+	Dm
		337715 Q9W4T9_DROME (222-594): 1.15e-10: 68.2: 22.28		SRC64_DROME (38-536): 2.25e-175: 507: 49.00
+	Hs
		789014 TUTLB_HUMAN (520-1036): 2.89e-18: 93.2: 26.47		TEC_HUMAN (5-529): 6.12e-163: 478: 34.89