HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 189
+	Hs
		349006 PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		349341 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		1070456 PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		349552 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		349308 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		1070208 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		348654 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		RASN_HUMAN (1-189): 2.37e-85: 251: 85.19
+	Hs
		350683 PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		1045419 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		914068 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		350195 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		914458 PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		350157 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		914091 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Mm
		1141162 GRB2_MOUSE (615-669): 2.48e-14: 74.6: 28.57		RAB13_MOUSE (4-188): 2.76e-75: 226: 35.05
+	Hs
		914272 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		914061 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88