HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	26871637
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 377
+	Hs
		235483 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		208967 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		3133 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		A0A0S2Z4D7_HUMAN (105-253): 4.97e-18: 82.5: 20.40
+	Mm
		223015 SRBS1_MOUSE (88-671): 6.32e-41: 162: 25.89		NCK2_MOUSE (1-376): 3.75e-90: 277: 66.93
+	Rn
		71363 SRC8_RAT (431-669): 1.65e-20: 97.4: 17.16		B2RZ33_RAT (1-377): 8.61e-99: 300: 99.20
+	Hs
		209154 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		298959 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		298942 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Rn
		192738 SPTN1_RAT (180-622): 1.15e-38: 156: 15.27		SRBS2_RAT (3-162): 4.86e-25: 109: 28.05
+	Hs
		789066 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Mm
		1141129 VAV2_MOUSE (170-436): 4.53e-30: 128: 15.31		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		655386 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Mm
		763400 PLCG2_MOUSE (475-671): 1.83e-16: 85.8: 13.07		FYN_MOUSE (7-173): 7.13e-21: 96: 15.39
+	Hs
		522981 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		523130 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		924570 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		275185 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		1078828 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Hs
		433350 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		1078886 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76