HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	21516116, 25416956, 16374509
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, filter binding, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 524
+	Hs
		235479 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79
+	Hs
		235471 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Hs
		298975 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		1026907 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		1026944 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		1026931 SH3R3_HUMAN (81-579): 2.19e-16: 85.4: 11.58		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		298951 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79
+	Hs
		1026936 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		1026928 SH3R1_HUMAN (526-671): 6.39e-13: 74.1: 26.03		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		1026163 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63
+	Hs
		596215 NEBU_HUMAN (12-671): 4.58e-53: 200: 12.62		STK3_HUMAN (224-524): 1.89e-125: 377: 41.25
+	Hs
		1026202 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63
+	Hs
		277606 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71
+	Hs
		682008 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	Hs
		682191 SH3R1_HUMAN (526-671): 6.39e-13: 74.1: 26.03		AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79
+	Hs
		235609 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		PAK5_HUMAN (67-179): 3.87e-12: 70.7: 25.64
+	Hs
		681922 SH3R1_HUMAN (526-671): 6.39e-13: 74.1: 26.03		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	Hs
		1052339 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		STK26_HUMAN (241-513): 3.68e-66: 221: 45.09
+	Hs
		331051 SH3R2_HUMAN (188-477): 1.41e-16: 85.8: 15.03		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55
+	Hs
		331005 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55