HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16189514
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 982
+	Hs
		298976 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Hs
		235473 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		CBL_HUMAN (25-976): 0: 675: 47.10
+	Mm
		1112057 SRBS1_MOUSE (88-671): 6.32e-41: 162: 25.89		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Mm
		82736 VAV2_MOUSE (170-436): 4.53e-30: 128: 15.31		B9EKI5_MOUSE (1-982): 0: 852: 90.53
+	Mm
		292684 GRAP2_MOUSE (182-436): 6.06e-24: 105: 14.79		CBLB_MOUSE (1-982): 0: 873: 95.12
+	Hs
		275194 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		CBLB_HUMAN (1-982): 0: 877: 100.00
+	Mm
		610595 SRBS2_MOUSE (56-671): 5.81e-63: 229: 27.24		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		298949 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		CBL_HUMAN (25-976): 0: 675: 47.10
+	Dm
		112567 M9ND00_DROME (44-544): 9.5e-32: 134: 15.98		O46034_DROME (27-434): 0: 718: 71.39
+	Mm
		610608 SRBS1_MOUSE (88-671): 6.32e-41: 162: 25.89		CBL_MOUSE (25-976): 0: 674: 47.47
+	Mm
		292681 GRAP2_MOUSE (182-436): 6.06e-24: 105: 14.79		CBL_MOUSE (25-976): 0: 674: 47.47
+	Hs
		610400 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		610501 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		275173 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		CBL_HUMAN (25-976): 0: 675: 47.10
+	Hs
		1052348 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		CBLC_HUMAN (29-497): 0: 585: 44.65
+	Hs
		203191 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		203192 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Rn
		192744 SRBS2_RAT (56-671): 3.74e-63: 229: 27.36		SYNJ1_RAT (687-978): 9.27e-09: 62: 10.51
+	Hs
		203250 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35
+	Hs
		203262 PACN2_HUMAN (433-671): 4.38e-18: 89.7: 15.98		SYNJ1_HUMAN (356-779): 6.17e-15: 82: 6.35