HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21653829
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, SH3_1~SH3_2, Ank_2~SH3_9, SH3_2~SH3_9
Common GO terms	GO:0000165 - MAPK cascade GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 1731
+	Hs
		298999 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		561160 SPTN1_MOUSE (180-622): 2.42e-38: 155: 15.27		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		82760 B9EKJ1_MOUSE (180-622): 2.42e-38: 155: 15.27		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Rn
		555260 SPTN1_RAT (180-622): 1.15e-38: 156: 15.27		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Hs
		1052307 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1078902 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1045505 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Mm
		1115913 GRB2_MOUSE (615-669): 2.48e-14: 74.6: 28.57		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		1052351 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		SHAN2_HUMAN (7-1728): 1.45e-124: 434: 40.04
+	Mm
		82740 B9EKJ1_MOUSE (180-622): 2.42e-38: 155: 15.27		ANK3_MOUSE (120-691): 8.6e-55: 214: 14.98
+	Hs
		862039 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		862037 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		965102 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		1021399 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		1263386 SH3K1_HUMAN (614-671): 3.44e-13: 74.9: 25.86		CSKI2_HUMAN (187-1345): 1.46e-34: 147: 14.44
+	Mm
		561172 SPTN1_MOUSE (180-622): 2.42e-38: 155: 15.27		ANK2_MOUSE (134-336): 2.34e-09: 65.1: 29.56
+	Dm
		1360790 Q9VA36_DROME (617-671): 1.41e-10: 66.7: 29.09		TNKS_DROME (220-561): 2.6e-31: 136: 11.88
+	Hs
		1045573 SPTN1_HUMAN (511-671): 1.08e-12: 73.9: 9.94		SHAN1_HUMAN (320-1726): 3.34e-22: 107: 13.60
+	Hs
		1078859 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50