HitPredict

Interactor 1: VINEX (O60504)
Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
Gene: SORBS3

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 454
+	Hs
		299002 SRBS2_HUMAN (56-671): 2.3e-57: 212: 26.28		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		1052318 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		275229 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		235470 VINEX_HUMAN (1-671): 2.64e-132: 406: 100.00		NCK1_HUMAN (346-428): 3.27e-14: 75.7: 30.95
+	Mm
		1143909 SRBS1_MOUSE (88-671): 6.32e-41: 162: 25.89		SH2B2_MOUSE (141-443): 1.84e-52: 188: 17.36
+	Hs
		145988 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		SH2B2_HUMAN (141-444): 7.08e-52: 186: 17.63
+	Mm
		1141129 VAV2_MOUSE (170-436): 4.53e-30: 128: 15.31		GRB2_MOUSE (310-454): 9.77e-43: 151: 24.83
+	Mm
		729760 PLCG2_MOUSE (475-671): 1.83e-16: 85.8: 13.07		BTK_MOUSE (137-445): 3.74e-52: 187: 11.85
+	Hs
		561388 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		FER_HUMAN (147-445): 1.31e-41: 159: 16.99
+	Hs
		522981 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		523130 SRBS1_HUMAN (522-671): 2.49e-20: 98.4: 35.53		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		433350 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		YES_HUMAN (201-454): 1.68e-41: 156: 15.44
+	Hs
		924570 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		275185 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		562646 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		PLCG2_HUMAN (98-454): 9.6e-30: 125: 15.11
+	Hs
		796571 SRC8_HUMAN (482-669): 6.12e-21: 98.9: 14.89		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08
+	Rn
		71363 SRC8_RAT (431-669): 1.65e-20: 97.4: 17.16		B2RZ33_RAT (346-428): 2.78e-14: 76.1: 30.95
+	Hs
		655386 ITSN1_HUMAN (434-671): 1.7e-15: 82.7: 15.02		P85A_HUMAN (341-451): 2.42e-18: 90: 24.14
+	Hs
		275178 GRAP2_HUMAN (182-436): 9.34e-19: 90.1: 12.83		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08
+	Mm
		815739 PLCG2_MOUSE (475-671): 1.83e-16: 85.8: 13.07		KSYK_MOUSE (279-440): 4.54e-15: 79.5: 23.64