HitPredict

Interactor 1: PRP17 (O60508)
Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)
Gene: CDC40

Interactor 2: WDR83 (Q9BRX9)
WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)
Gene: WDR83

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 579 Hs			1 315
+	Dm
		1363493 Q9VD52_DROME (9-579): 5.43e-139: 417: 61.29		Q9VYQ9_DROME (2-313): 9.5e-88: 272: 21.78
+	Hs
		236246 PRP17_HUMAN (30-579): 1.21e-144: 431: 100.00		SNR40_HUMAN (101-312): 1.44e-55: 185: 18.47
+	Dm
		1363491 Q9VD52_DROME (9-579): 5.43e-139: 417: 61.29		Q9VPL0_DROME (2-217): 1.78e-56: 187: 20.26
+	Sp
		195181 PRP17_SCHPO (29-579): 2.23e-108: 337: 39.39		YN55_SCHPO (28-288): 7.99e-72: 225: 41.60
+	Hs
		1288273 SNR40_HUMAN (324-579): 4.45e-65: 218: 19.85		WDR83_HUMAN (1-315): 2.96e-102: 303: 100.00
+	Mm
		925836 LIS1_MOUSE (182-491): 2.14e-81: 263: 19.82		LIS1_MOUSE (63-312): 6.3e-76: 239: 19.78
+	Hs
		792935 LIS1_HUMAN (182-491): 3.27e-81: 262: 19.82		LIS1_HUMAN (63-312): 8.99e-76: 239: 19.78
+	Hs
		209467 SNR40_HUMAN (324-579): 4.45e-65: 218: 19.85		PLRG1_HUMAN (2-312): 1.61e-88: 275: 23.15
+	Hs
		209416 WDR5_HUMAN (95-445): 1.64e-63: 213: 15.54		PLRG1_HUMAN (2-312): 1.61e-88: 275: 23.15
+	Hs
		792949 LIS1_HUMAN (182-491): 3.27e-81: 262: 19.82		WDR5_HUMAN (140-312): 2.71e-53: 178: 23.60
+	Sp
		195162 PRP17_SCHPO (29-579): 2.23e-108: 337: 39.39		CWF17_SCHPO (28-294): 2.22e-21: 94.4: 27.05
+	Hs
		1240442 POC1A_HUMAN (318-579): 5.89e-76: 248: 22.81		POC1B_HUMAN (2-181): 1.28e-52: 181: 21.43
+	Sp
		141987 PRP17_SCHPO (29-579): 2.23e-108: 337: 39.39		PRP46_SCHPO (14-267): 6.43e-20: 91.7: 26.07
+	Sp
		195143 PRP17_SCHPO (29-579): 2.23e-108: 337: 39.39		PRP17_SCHPO (224-306): 1.02e-11: 67.5: 16.47
+	Hs
		903428 SNR40_HUMAN (324-579): 4.45e-65: 218: 19.85		WDR5_HUMAN (140-312): 2.71e-53: 178: 23.60
+	Hs
		903077 WDR5_HUMAN (95-445): 1.64e-63: 213: 15.54		WDR5_HUMAN (140-312): 2.71e-53: 178: 23.60
+	Hs
		903349 WDR5_HUMAN (95-445): 1.64e-63: 213: 15.54		WDR5B_HUMAN (138-312): 8.72e-50: 170: 22.22
+	Sc
		630844 NLE1_YEAST (166-579): 2.01e-84: 274: 15.45		NLE1_YEAST (2-94): 1.96e-23: 101: 30.11