HitPredict

Interactor 1: 4EBP3 (O60516)
Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)
Gene: EIF4EBP3

Interactor 2: IF4E2 (O60573)
Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
Gene: EIF4E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	16189514, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	IF4E~eIF_4EBP
Common GO terms	GO:0005737 - cytoplasm GO:0016281 - eukaryotic translation initiation factor 4F complex GO:0045947 - negative regulation of translational initiation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 100 Hs			1 245
+	Hs
		237212 4EBP2_HUMAN (15-100): 2.24e-39: 128: 59.78		IF4E2_HUMAN (1-245): 5.31e-141: 396: 100.00
+	Hs
		237211 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		IF4E2_HUMAN (1-245): 5.31e-141: 396: 100.00
+	Mm
		1141831 4EBP1_MOUSE (17-100): 1.03e-32: 111: 57.96		IF4E2_MOUSE (1-245): 1.18e-140: 395: 98.37
+	Hs
		236380 4EBP3_HUMAN (1-100): 3.02e-45: 142: 100.00		IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40
+	Mm
		926368 4EBP2_MOUSE (15-100): 2.04e-38: 126: 57.61		IF4E_MOUSE (28-233): 1.11e-92: 273: 31.75
+	Hs
		416983 4EBP2_HUMAN (15-100): 2.24e-39: 128: 59.78		IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40
+	Rn
		926380 4EBP1_RAT (17-100): 4.29e-35: 117: 57.96		IF4E_RAT (28-233): 1.11e-92: 273: 31.75
+	Mm
		926370 4EBP1_MOUSE (17-100): 1.03e-32: 111: 57.96		IF4E_MOUSE (28-233): 1.11e-92: 273: 31.75
+	Hs
		416982 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40
+	Hs
		64108 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		I4E1B_HUMAN (28-233): 8.57e-87: 259: 32.41
+	Dm
		820469 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		IF4E_DROME (17-230): 8.97e-85: 254: 30.88
+	Dm
		1376673 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9W5B3_DROME (32-230): 2.86e-80: 248: 32.67
+	Dm
		1373363 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VRY0_DROME (22-229): 5.91e-82: 246: 33.65
+	Dm
		1373550 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VSB6_DROME (5-230): 1.98e-78: 237: 27.95
+	Dm
		1373609 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VSG1_DROME (51-225): 2.04e-74: 227: 31.46