HitPredict

Interactor 1: 4EBP3 (O60516)
Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)
Gene: EIF4EBP3

Interactor 2: IF4E (P06730)
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Gene: EIF4E

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	33961781, 12482586, 9593750, 25416956, 32296183, 24722188, unassigned1304, 15153109
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, anti tag coimmunoprecipitation, pull down, coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, far western blotting
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	IF4E~eIF_4EBP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016281 - eukaryotic translation initiation factor 4F complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 100 Hs			1 217
+	Hs
		416983 4EBP2_HUMAN (15-100): 2.24e-39: 128: 59.78		IF4E_HUMAN (1-217): 1.05e-109: 315: 100.00
+	Mm
		926368 4EBP2_MOUSE (15-100): 2.04e-38: 126: 57.61		IF4E_MOUSE (1-217): 1.95e-110: 317: 98.16
+	Rn
		926380 4EBP1_RAT (17-100): 4.29e-35: 117: 57.96		IF4E_RAT (1-217): 1.95e-110: 317: 98.16
+	Hs
		416982 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		IF4E_HUMAN (1-217): 1.05e-109: 315: 100.00
+	Mm
		926370 4EBP1_MOUSE (17-100): 1.03e-32: 111: 57.96		IF4E_MOUSE (1-217): 1.95e-110: 317: 98.16
+	Hs
		236378 4EBP3_HUMAN (1-100): 3.02e-45: 142: 100.00		IF4E2_HUMAN (7-216): 3.13e-89: 264: 29.86
+	Dm
		820469 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		IF4E_DROME (5-217): 9.46e-99: 288: 47.89
+	Hs
		64108 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		I4E1B_HUMAN (37-217): 4.21e-96: 281: 74.03
+	Hs
		237212 4EBP2_HUMAN (15-100): 2.24e-39: 128: 59.78		IF4E2_HUMAN (7-216): 3.13e-89: 264: 29.86
+	Dm
		1373363 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VRY0_DROME (7-217): 1.07e-94: 277: 45.37
+	Dm
		1376673 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9W5B3_DROME (36-217): 8.1e-88: 267: 48.90
+	Hs
		237211 4EBP1_HUMAN (17-100): 5.79e-34: 114: 56.82		IF4E2_HUMAN (7-216): 3.13e-89: 264: 29.86
+	Mm
		1141831 4EBP1_MOUSE (17-100): 1.03e-32: 111: 57.96		IF4E2_MOUSE (7-216): 2.94e-88: 261: 29.41
+	Dm
		1373550 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VSB6_DROME (6-217): 8.21e-87: 257: 40.57
+	Dm
		1373609 4EBP_DROME (15-100): 1.89e-33: 113: 44.44		Q9VSG1_DROME (14-217): 3.46e-85: 254: 39.32