HitPredict

Interactor 1: IF4E2 (O60573)
Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
Gene: EIF4E2

Interactor 2: 4EBP2 (Q13542)
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)
Gene: EIF4EBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	IF4E~eIF_4EBP
Common GO terms	GO:0005737 - cytoplasm GO:0045947 - negative regulation of translational initiation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 120
+	Hs
		237211 IF4E2_HUMAN (1-245): 5.31e-141: 396: 100.00		4EBP1_HUMAN (4-120): 6.06e-46: 146: 57.14
+	Mm
		1141831 IF4E2_MOUSE (1-245): 1.18e-140: 395: 98.37		4EBP1_MOUSE (4-120): 3.13e-44: 141: 58.48
+	Hs
		236378 IF4E2_HUMAN (1-245): 5.31e-141: 396: 100.00		4EBP3_HUMAN (29-120): 8.66e-31: 107: 59.78
+	Mm
		926368 IF4E_MOUSE (28-233): 1.11e-92: 273: 31.75		4EBP2_MOUSE (1-120): 9.09e-59: 178: 95.00
+	Hs
		416983 IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40		4EBP2_HUMAN (1-120): 7.22e-59: 178: 100.00
+	Rn
		926380 IF4E_RAT (28-233): 1.11e-92: 273: 31.75		4EBP1_RAT (4-120): 3.48e-47: 149: 58.48
+	Hs
		416982 IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40		4EBP1_HUMAN (4-120): 6.06e-46: 146: 57.14
+	Mm
		926370 IF4E_MOUSE (28-233): 1.11e-92: 273: 31.75		4EBP1_MOUSE (4-120): 3.13e-44: 141: 58.48
+	Hs
		64108 I4E1B_HUMAN (28-233): 8.57e-87: 259: 32.41		4EBP1_HUMAN (4-120): 6.06e-46: 146: 57.14
+	Dm
		820469 IF4E_DROME (17-230): 8.97e-85: 254: 30.88		4EBP_DROME (1-120): 1.31e-46: 147: 39.17
+	Dm
		1376673 Q9W5B3_DROME (32-230): 2.86e-80: 248: 32.67		4EBP_DROME (1-120): 1.31e-46: 147: 39.17
+	Dm
		1373363 Q9VRY0_DROME (22-229): 5.91e-82: 246: 33.65		4EBP_DROME (1-120): 1.31e-46: 147: 39.17
+	Dm
		1373550 Q9VSB6_DROME (5-230): 1.98e-78: 237: 27.95		4EBP_DROME (1-120): 1.31e-46: 147: 39.17
+	Hs
		236380 IF4E_HUMAN (32-233): 2.86e-91: 269: 31.40		4EBP3_HUMAN (29-120): 8.66e-31: 107: 59.78
+	Dm
		1373609 Q9VSG1_DROME (51-225): 2.04e-74: 227: 31.46		4EBP_DROME (1-120): 1.31e-46: 147: 39.17