HitPredict

Interactor 1: TLR5 (O60602)
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Gene: TLR5

Interactor 2: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20855887
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002224 - toll-like receptor signaling pathway GO:0006954 - inflammatory response GO:0045087 - innate immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 712
+	Hs
		120161 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		TCAM1_HUMAN (1-712): 0: 1002: 100.00
+	Hs
		237502 TLR2_HUMAN (3-499): 3.23e-17: 88.7: 14.47		TCAM1_HUMAN (1-712): 0: 1002: 100.00
+	Hs
		179947 TLR3_HUMAN (2-322): 1.33e-15: 83.3: 15.66		TCAM1_HUMAN (1-712): 0: 1002: 100.00
+	Mm
		1193561 TLR3_MOUSE (2-361): 1.12e-14: 80.6: 15.95		TCAM1_MOUSE (5-712): 0: 981: 53.34
+	Mm
		1193564 TLR4_MOUSE (182-684): 2.6e-12: 72.9: 16.14		TCAM1_MOUSE (5-712): 0: 981: 53.34
+	Hs
		120160 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		TCAM2_HUMAN (394-545): 2.01e-70: 231: 33.33
+	Mm
		1206754 TLR3_MOUSE (2-361): 1.12e-14: 80.6: 15.95		TCAM2_MOUSE (367-552): 5.5e-72: 235: 31.58
+	Mm
		1206756 TLR4_MOUSE (182-684): 2.6e-12: 72.9: 16.14		TCAM2_MOUSE (367-552): 5.5e-72: 235: 31.58