HitPredict

Interactor 1: TLR5 (O60602)
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Gene: TLR5

Interactor 2: SIG11 (Q96RL6)
Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)
Gene: SIGLEC11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 698
+	Hs
		1297092 TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25		SIG10_HUMAN (28-672): 1.09e-103: 333: 68.43
+	Hs
		177608 TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Hs
		120171 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		SIG11_HUMAN (1-698): 2.88e-133: 410: 100.00
+	Hs
		211424 TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25		SIGL6_HUMAN (166-458): 2.26e-43: 164: 27.30
+	Hs
		1344389 TLR8_HUMAN (2-846): 2.26e-100: 337: 20.25		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Mm
		1265316 TLR5_MOUSE (4-469): 7.82e-29: 126: 14.13		SIGL5_MOUSE (14-675): 1.14e-101: 324: 29.96
+	Mm
		1144431 TLR5_MOUSE (4-469): 7.82e-29: 126: 14.13		CD33_MOUSE (14-248): 1.83e-88: 284: 44.26
+	Hs
		177591 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Hs
		120112 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Dr
		1265014 Q9DE36_DANRE (10-348): 6.5e-25: 114: 16.62		Q90Z70_DANRE (3-691): 9.06e-70: 250: 12.83
+	Dr
		65452 Q9DE36_DANRE (10-348): 6.5e-25: 114: 16.62		A8DZ85_DANRE (3-691): 2.49e-64: 234: 13.40
+	Hs
		237425 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		CD22_HUMAN (75-662): 2.09e-42: 166: 17.41
+	Hs
		211412 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		SIGL6_HUMAN (166-458): 2.26e-43: 164: 27.30
+	Hs
		237442 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Hs
		120114 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		SIGL6_HUMAN (166-458): 2.26e-43: 164: 27.30
+	Hs
		120187 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Mm
		722909 TLR5_MOUSE (4-469): 7.82e-29: 126: 14.13		CD22_MOUSE (99-466): 1.88e-31: 133: 21.93
+	Hs
		237440 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		SIGL7_HUMAN (160-455): 2.09e-31: 130: 28.79
+	Hs
		237424 TLR5_HUMAN (2-423): 2.78e-29: 127: 16.57		CD33_HUMAN (372-674): 1.45e-25: 110: 22.76
+	Hs
		120185 TLR4_HUMAN (2-229): 1.83e-22: 105: 17.19		SIGL7_HUMAN (160-455): 2.09e-31: 130: 28.79