Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: CD14 (P08571)
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]
Gene: CD14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 10395652, 18765807, 11986301
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, solid phase assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_1~LRR_6, LRR_6~LRR_8
Common GO terms GO:0001530 - lipopolysaccharide binding
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
and 9 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 784
Hs

1 375
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024