HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: BLK (P51451)
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
Gene: BLK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 784 Hs			1 505
+	Hs
		237456 TLR2_HUMAN (1-784): 1.1e-125: 396: 100.00		LYN_HUMAN (1-505): 0: 551: 59.77
+	Hs
		179930 TLR3_HUMAN (1-784): 7.57e-85: 290: 17.94		BLK_HUMAN (1-505): 0: 600: 100.00
+	Hs
		179925 TLR3_HUMAN (1-784): 7.57e-85: 290: 17.94		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		120129 TLR4_HUMAN (11-782): 2.16e-83: 285: 22.77		SRC_HUMAN (1-503): 0: 560: 54.22
+	Mm
		403461 TLR4_MOUSE (1-782): 1.72e-81: 279: 21.33		SRC_MOUSE (1-503): 0: 557: 54.51
+	Mm
		403457 TLR3_MOUSE (10-784): 4.34e-78: 272: 18.51		SRC_MOUSE (1-503): 0: 557: 54.51
+	Hs
		986405 TLR6_HUMAN (36-781): 2.39e-94: 313: 28.14		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		120149 TLR4_HUMAN (11-782): 2.16e-83: 285: 22.77		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Mm
		403459 TLR9_MOUSE (6-533): 5.1e-33: 139: 15.95		SRC_MOUSE (1-503): 0: 557: 54.51
+	Hs
		523168 TLR9_HUMAN (3-269): 2.05e-24: 111: 14.18		SRC_HUMAN (1-503): 0: 560: 54.22
+	Hs
		986400 TLR9_HUMAN (3-269): 2.05e-24: 111: 14.18		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12
+	Hs
		986401 TLR8_HUMAN (12-265): 4.18e-22: 104: 17.58		BTK_HUMAN (4-498): 2.89e-156: 461: 34.12