HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: TLR1 (Q15399)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.885

The method score is based on:

Property Details
Experiments 12077222, 16848791, 20348427, 23155421
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tox-r dimerization assay, fluorescent resonance energy transfer
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_1~LRR_8, LRR_8~LRR_8, LRR_8~LRRCT, TIR~TIR
Common GO terms GO:0002224 - toll-like receptor signaling pathway
GO:0004888 - transmembrane signaling receptor activity
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
and 14 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 784
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024