Interactor 1: GFRA3 (O60609)
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)
Gene: GFRA3

Interactor 2: ARTN (Q5T4W7)
Artemin (Enovin) (Neublastin)
Gene: ARTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.820

The method score is based on:

Property Details
Experiments 9883723, 16765900
Identification Methods pull down, light scattering, isothermal titration calorimetry, molecular sieving, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains GDNF~TGF_beta
Common GO terms GO:0005102 - signaling receptor binding
GO:0007165 - signal transduction
GO:0007422 - peripheral nervous system development
GO:0035860 - glial cell-derived neurotrophic factor receptor signaling pathway
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 400
Hs

1 220
+ Mm
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024