HitPredict

Interactor 1: DIAP1 (O60610)
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Gene: DIAPH1

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1272 Hs			1 192
+	Hs
		237586 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		237588 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		237577 DIAP1_HUMAN (1-1272): 0: 953: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		237579 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		237551 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		243100 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		243089 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		243112 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		925658 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		243095 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		243101 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		243096 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		243097 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		545645 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		243091 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		892621 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		894489 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900958 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436532 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564704 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49