HitPredict

Interactor 1: DIAP1 (O60610)
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Gene: DIAPH1

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31478661
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization and 1 others more... GO:0072686 - mitotic spindle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1272 Hs			1 191
+	Hs
		237586 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		237588 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		237579 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		237551 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		237576 DIAP1_HUMAN (1-1272): 0: 953: 100.00		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		243091 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		564704 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		243112 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Hs
		243100 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		243096 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		243101 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		243097 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		243089 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		925658 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		243095 DIAP2_HUMAN (12-509): 2.42e-128: 424: 45.88		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Hs
		894489 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		900958 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545645 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436532 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		892621 DIAP3_HUMAN (755-1234): 1.41e-122: 411: 57.47		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32