HitPredict

Interactor 1: AP180 (O60641)
Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)
Gene: SNAP91

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32812023, 35063084
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 907 Hs			1 758
+	Hs
		92404 E9PDG8_HUMAN (1-907): 5.03e-127: 407: 98.57		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Mm
		498045 AP180_MOUSE (1-907): 9.5e-127: 406: 91.53		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Rn
		581990 AP180_RAT (1-907): 4.12e-116: 378: 87.93		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94212 AP180_RAT (1-907): 4.12e-116: 378: 87.93		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Hs
		149945 NCAN_HUMAN (314-896): 1.55e-13: 77: 14.48		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		582007 SYNJ1_RAT (252-705): 2.72e-09: 63.6: 12.78		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94231 SYNJ1_RAT (252-705): 2.72e-09: 63.6: 12.78		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		88453 D3Z656_MOUSE (479-905): 6.87e-13: 75.1: 10.12		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		554259 MUC1_HUMAN (393-898): 1.67e-22: 106: 12.62		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84
+	Dm
		113976 M9PB30_DROME (265-682): 7.8e-20: 98.2: 12.68		M9PB30_DROME (69-755): 2.38e-24: 112: 8.39
+	Hs
		152667 KMT2C_HUMAN (337-898): 6.04e-15: 82.1: 10.60		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		1056827 MDC1_HUMAN (286-766): 3.05e-09: 63.1: 17.14		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Mm
		1207212 KMT2C_MOUSE (413-898): 9.8e-11: 68.1: 15.13		NCOA6_MOUSE (23-739): 1.31e-24: 112: 9.76
+	Mm
		1351630 PCLO_MOUSE (465-897): 5.15e-09: 62.8: 15.14		PCLO_MOUSE (6-742): 3.27e-11: 69.3: 9.66