HitPredict

Interactor 1: AP180 (O60641)
Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)
Gene: SNAP91

Interactor 2: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	12807910, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005905 - clathrin-coated pit GO:0015031 - protein transport GO:0048268 - clathrin coat assembly
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 907 Hs			1 896
+	Hs
		787907 PICAL_HUMAN (548-879): 3.59e-16: 85.1: 29.20		EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00
+	Ce
		1353623 PICAL_CAEEL (3-514): 1.21e-112: 359: 40.73		Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85
+	Rn
		1126747 SYNJ1_RAT (252-705): 2.72e-09: 63.6: 12.78		Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79
+	Sc
		710396 AP18B_YEAST (20-516): 2.05e-74: 256: 18.64		EDE1_YEAST (3-327): 3e-15: 82.9: 24.01
+	Sc
		759249 AP18B_YEAST (20-516): 2.05e-74: 256: 18.64		END3_YEAST (15-378): 4.53e-13: 73.6: 17.73
+	Sc
		704769 SLA2_YEAST (16-376): 3.81e-64: 235: 17.32		EDE1_YEAST (3-327): 3e-15: 82.9: 24.01
+	Sc
		704779 SLA2_YEAST (16-376): 3.81e-64: 235: 17.32		END3_YEAST (15-378): 4.53e-13: 73.6: 17.73
+	Hs
		1036409 PICAL_HUMAN (548-879): 3.59e-16: 85.1: 29.20		ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61
+	Hs
		255255 ASPP1_HUMAN (262-710): 1.48e-09: 63.9: 14.11		LIPA3_HUMAN (222-883): 2.91e-31: 134: 12.39
+	Rn
		222940 PICAL_RAT (551-879): 9.52e-15: 80.5: 27.11		EHD2_RAT (19-102): 1.45e-12: 73.1: 27.38