HitPredict

Interactor 1: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Interactor 2: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 402 Hs			1 158
+	Hs
		238115 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61
+	Hs
		238123 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		LHX6_HUMAN (7-153): 2.16e-38: 135: 27.70
+	Hs
		238113 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		LMO3_HUMAN (30-156): 5.7e-39: 130: 58.27
+	Hs
		238099 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Hs
		899927 LMX1A_HUMAN (24-402): 5.5e-86: 268: 62.60		ISL1_HUMAN (22-148): 6.29e-41: 141: 34.38
+	Hs
		822660 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61
+	Hs
		899930 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61
+	Hs
		899916 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		ISL1_HUMAN (22-148): 6.29e-41: 141: 34.38
+	Hs
		1251463 LHX5_HUMAN (55-401): 6.85e-65: 214: 25.34		LMO3_HUMAN (30-156): 5.7e-39: 130: 58.27
+	Dm
		284834 APTE_DROME (16-312): 2.32e-61: 207: 26.45		O77284_DROME (26-151): 1.52e-39: 137: 55.56
+	Hs
		638252 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Hs
		839800 LHX2_HUMAN (33-353): 4.96e-57: 194: 22.37		ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61
+	Hs
		1255791 LMX1A_HUMAN (24-402): 5.5e-86: 268: 62.60		LHX3_HUMAN (92-155): 2.6e-12: 65: 23.44
+	Hs
		1255789 LMX1A_HUMAN (24-402): 5.5e-86: 268: 62.60		LMX1A_HUMAN (89-155): 3.3e-09: 56.1: 17.91
+	Hs
		822689 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		LHX3_HUMAN (92-155): 2.6e-12: 65: 23.44
+	Hs
		899935 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		LHX3_HUMAN (92-155): 2.6e-12: 65: 23.44
+	Ce
		104771 LIM7_CAEEL (44-402): 2.2e-51: 180: 23.46		LIN11_CAEEL (30-153): 1.14e-20: 88.6: 34.40
+	Mm
		839895 ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61		LHX3_MOUSE (83-155): 9.18e-12: 63.4: 19.18
+	Hs
		899929 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		LHX4_HUMAN (89-155): 5.05e-11: 61.5: 26.87