HitPredict

Interactor 1: LMX1B (O60663)
LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)
Gene: LMX1B

Interactor 2: SSBP4 (Q9BWG4)
Single-stranded DNA-binding protein 4
Gene: SSBP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 402 Hs			1 385
+	Hs
		238119 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		291998 LMX1B_MOUSE (1-402): 2.75e-99: 302: 98.01		Q3U4B1_MOUSE (1-385): 1.89e-54: 185: 83.68
+	Mm
		292011 LMX1B_MOUSE (1-402): 2.75e-99: 302: 98.01		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Hs
		238106 LMX1B_HUMAN (1-402): 2.14e-104: 316: 100.00		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		292010 LMX1B_MOUSE (1-402): 2.75e-99: 302: 98.01		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		822672 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Hs
		899932 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Hs
		1314654 LHX9_HUMAN (53-338): 1.07e-57: 195: 25.93		SSBP4_HUMAN (1-385): 6e-71: 228: 100.00
+	Mm
		1321889 LMX1A_MOUSE (24-402): 4.97e-85: 265: 62.60		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		822674 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Hs
		899933 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		899944 ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Mm
		1112385 LHX9_MOUSE (53-338): 2.16e-57: 194: 26.24		Q3U4B1_MOUSE (1-385): 1.89e-54: 185: 83.68
+	Hs
		1314903 LHX9_HUMAN (53-338): 1.07e-57: 195: 25.93		SSBP3_HUMAN (6-385): 7.32e-54: 184: 70.03
+	Mm
		1321929 LHX2_MOUSE (33-353): 8.22e-58: 195: 21.83		SSBP3_MOUSE (6-385): 7.32e-54: 184: 70.03
+	Hs
		822624 LHX1_HUMAN (55-400): 3.03e-63: 210: 25.34		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		899943 ISL1_MOUSE (49-389): 3.38e-62: 205: 28.61		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Hs
		899917 ISL1_HUMAN (49-389): 3.38e-62: 205: 28.61		SSBP2_HUMAN (1-385): 1.3e-43: 156: 69.51
+	Mm
		1321891 LHX2_MOUSE (33-353): 8.22e-58: 195: 21.83		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77
+	Mm
		1321890 LHX9_MOUSE (53-338): 2.16e-57: 194: 26.24		SSBP2_MOUSE (1-385): 5.05e-44: 157: 69.77