Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 10026141, 11087817, 8609418, 8041779, 15767667, 16609991, 24354892, 21841788, 22820988
Identification Methods enzymatic study, protein kinase assay
Interaction Type direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~FERM_F1, FERM_F1~FERM_F2, FERM_F1~Jak1_Phl, FERM_F1~SH2, FERM_F2~FERM_F2, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms GO:0000791 - euchromatin
GO:0001774 - microglial cell activation
GO:0002250 - adaptive immune response
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
and 127 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 1132
Hs

1 1132
+ Rn
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ At

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Last updated: 15 Jul 2024