HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9553136
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 551
+	Mm
		995942 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PRLR_MOUSE (6-456): 1.04e-96: 308: 14.22
+	Hs
		238338 JAK2_HUMAN (1-1132): 0: 1122: 100.00		GHR_HUMAN (7-485): 4.72e-75: 252: 16.57
+	Hs
		238348 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96
+	Hs
		238367 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81
+	Hs
		238353 JAK2_HUMAN (1-1132): 0: 1122: 100.00		EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49
+	Mm
		562614 JAK2_MOUSE (1-1129): 0: 1108: 93.89		GHR_MOUSE (22-522): 1.41e-61: 215: 14.69
+	Mm
		540270 JAK2_MOUSE (1-1129): 0: 1108: 93.89		EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30
+	Hs
		238398 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL5RA_HUMAN (17-297): 7.21e-54: 189: 15.84
+	Hs
		238358 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL4RA_HUMAN (1-483): 2.01e-42: 164: 17.49
+	Hs
		238434 JAK2_HUMAN (1-1132): 0: 1122: 100.00		I12R2_HUMAN (26-243): 6.78e-20: 95.7: 16.14
+	Hs
		238382 JAK2_HUMAN (1-1132): 0: 1122: 100.00		LEPR_HUMAN (33-243): 2.47e-19: 94.2: 16.74
+	Hs
		238368 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL3RB_HUMAN (13-240): 2.54e-16: 84.6: 17.01
+	Mm
		817305 JAK2_MOUSE (1-1129): 0: 1108: 93.89		LEPR_MOUSE (33-243): 2.07e-20: 97.6: 17.65
+	Mm
		956337 JAK2_MOUSE (1-1129): 0: 1108: 93.89		I12R2_MOUSE (26-243): 2.54e-19: 94.2: 17.65
+	Mm
		645934 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3B2_MOUSE (3-240): 6.68e-19: 92.7: 14.40
+	Hs
		238375 JAK2_HUMAN (1-1132): 0: 1122: 100.00		TPOR_HUMAN (1-235): 3.46e-14: 77.3: 13.68
+	Mm
		645936 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3RB_MOUSE (3-240): 3.28e-18: 90.4: 15.94
+	Hs
		238374 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL6RB_HUMAN (27-351): 1.04e-13: 76.1: 13.11
+	Mm
		960491 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL6RB_MOUSE (47-288): 1.34e-12: 72.7: 14.17
+	Mm
		994699 JAK2_MOUSE (1-1129): 0: 1108: 93.89		TPOR_MOUSE (7-251): 1.93e-12: 71.8: 15.20