HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	11779507, 8343951, 14982882
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 508
+	Mm
		540270 JAK2_MOUSE (1-1129): 0: 1108: 93.89		EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69
+	Mm
		562614 JAK2_MOUSE (1-1129): 0: 1108: 93.89		GHR_MOUSE (6-486): 3.15e-95: 304: 16.02
+	Hs
		238338 JAK2_HUMAN (1-1132): 0: 1122: 100.00		GHR_HUMAN (6-482): 1.38e-87: 283: 15.10
+	Hs
		238348 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03
+	Mm
		645936 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3RB_MOUSE (17-488): 6.93e-85: 282: 18.29
+	Mm
		995942 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PRLR_MOUSE (30-495): 6.85e-82: 268: 17.57
+	Hs
		238343 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52
+	Hs
		238367 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL2RG_HUMAN (15-351): 3.88e-59: 201: 17.35
+	Hs
		238398 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL5RA_HUMAN (24-301): 7.09e-53: 186: 18.31
+	Hs
		238358 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL4RA_HUMAN (48-496): 2.05e-38: 151: 14.78
+	Hs
		238434 JAK2_HUMAN (1-1132): 0: 1122: 100.00		I12R2_HUMAN (40-256): 3.49e-32: 133: 17.27
+	Mm
		956337 JAK2_MOUSE (1-1129): 0: 1108: 93.89		I12R2_MOUSE (17-256): 1.08e-36: 146: 17.74
+	Hs
		238382 JAK2_HUMAN (1-1132): 0: 1122: 100.00		LEPR_HUMAN (49-259): 5.61e-29: 123: 12.50
+	Mm
		960491 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL6RB_MOUSE (19-483): 1.95e-33: 137: 13.92
+	Hs
		238375 JAK2_HUMAN (1-1132): 0: 1122: 100.00		TPOR_HUMAN (21-399): 4.82e-27: 116: 19.08
+	Hs
		238374 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL6RB_HUMAN (64-483): 1.74e-23: 106: 12.72
+	Mm
		994699 JAK2_MOUSE (1-1129): 0: 1108: 93.89		TPOR_MOUSE (50-349): 4.29e-24: 108: 21.98
+	Mm
		817305 JAK2_MOUSE (1-1129): 0: 1108: 93.89		LEPR_MOUSE (49-258): 1.18e-21: 101: 16.22
+	Hs
		238368 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL3RB_HUMAN (17-244): 4.61e-09: 61.2: 14.34
+	Mm
		645934 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3B2_MOUSE (46-244): 3.71e-10: 64.6: 15.57