HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 0.60 0.711

The method score is based on:

Property Details
Experiments 7775438, 7527392, 21965659, 18692472, 16437163
Identification Methods pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0019221 - cytokine-mediated signaling pathway
GO:0030526 - granulocyte macrophage colony-stimulating factor receptor complex
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1132
Hs

1 897
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024