HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: INGR2 (P38484)
Interferon gamma receptor 2 (IFN-gamma receptor 2) (IFN-gamma-R2) (Interferon gamma receptor accessory factor 1) (AF-1) (Interferon gamma receptor beta-chain) (IFN-gamma-R-beta) (Interferon gamma transducer 1)
Gene: IFNGR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	7673114
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001774 - microglial cell activation GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway GO:0060333 - type II interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 337
+	Mm
		1143570 JAK2_MOUSE (1-1129): 0: 1108: 93.89		Q63953_MOUSE (16-336): 1.04e-104: 311: 58.51
+	Mm
		546500 JAK2_MOUSE (1-1129): 0: 1108: 93.89		INGR1_MOUSE (1-327): 4.07e-63: 209: 16.07
+	Hs
		238344 JAK2_HUMAN (1-1132): 0: 1122: 100.00		INGR1_HUMAN (27-332): 1.54e-43: 158: 16.57
+	Hs
		238348 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PRLR_HUMAN (28-287): 1.16e-09: 61.5: 16.91
+	Mm
		960491 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL6RB_MOUSE (25-246): 8.5e-11: 65: 16.96
+	Hs
		566003 TYK2_HUMAN (38-1132): 0: 870: 35.49		INAR1_HUMAN (1-253): 5.02e-25: 107: 21.48
+	Hs
		522745 SRC_HUMAN (820-1131): 6.64e-99: 326: 25.88		INGR1_HUMAN (27-332): 1.54e-43: 158: 16.57
+	Hs
		411611 LCK_HUMAN (801-1132): 4.46e-98: 322: 29.13		EPHA2_HUMAN (32-229): 1.92e-09: 61.1: 19.50
+	Hs
		433601 LYN_HUMAN (793-1132): 2.7e-93: 309: 29.91		EPHA2_HUMAN (32-229): 1.92e-09: 61.1: 19.50
+	Hs
		616765 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		INAR2_HUMAN (10-330): 3.2e-62: 208: 15.85
+	Hs
		616825 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		I20RB_HUMAN (1-329): 8.66e-64: 206: 23.72
+	Hs
		616805 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		I10R1_HUMAN (28-313): 8.83e-58: 197: 18.46
+	Hs
		546433 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		INGR1_HUMAN (27-332): 1.54e-43: 158: 16.57
+	Hs
		616833 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		INLR1_HUMAN (30-237): 3.48e-41: 152: 16.04
+	Hs
		565998 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		INAR1_HUMAN (1-253): 5.02e-25: 107: 21.48
+	Hs
		507827 FGFR1_HUMAN (545-838): 5.95e-13: 75.5: 22.57		INGR1_HUMAN (27-332): 1.54e-43: 158: 16.57
+	Hs
		507837 FGFR1_HUMAN (545-838): 5.95e-13: 75.5: 22.57		INAR1_HUMAN (1-253): 5.02e-25: 107: 21.48
+	Hs
		384329 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		EPHA2_HUMAN (32-229): 1.92e-09: 61.1: 19.50
+	Mm
		1186724 PTK7_MOUSE (550-805): 1.27e-16: 87.4: 25.74		Q7TQG5_MOUSE (18-215): 1.71e-09: 61.1: 16.75
+	Hs
		507871 FGFR1_HUMAN (545-838): 5.95e-13: 75.5: 22.57		EPHA2_HUMAN (32-229): 1.92e-09: 61.1: 19.50