HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	9516124
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019221 - cytokine-mediated signaling pathway GO:0038043 - interleukin-5-mediated signaling pathway GO:0070665 - positive regulation of leukocyte proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 420
+	Hs
		238348 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PRLR_HUMAN (137-396): 9.33e-58: 201: 19.27
+	Mm
		995942 JAK2_MOUSE (1-1129): 0: 1108: 93.89		PRLR_MOUSE (137-396): 6.73e-57: 198: 18.18
+	Mm
		645932 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3RA_MOUSE (4-404): 1.41e-56: 193: 15.96
+	Hs
		238367 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL2RG_HUMAN (80-400): 8.91e-48: 168: 17.26
+	Hs
		238434 JAK2_HUMAN (1-1132): 0: 1122: 100.00		I12R2_HUMAN (67-342): 2.72e-43: 163: 14.89
+	Hs
		238338 JAK2_HUMAN (1-1132): 0: 1122: 100.00		GHR_HUMAN (106-398): 9.47e-43: 160: 17.54
+	Mm
		562614 JAK2_MOUSE (1-1129): 0: 1108: 93.89		GHR_MOUSE (106-398): 4.77e-42: 158: 15.46
+	Mm
		540270 JAK2_MOUSE (1-1129): 0: 1108: 93.89		EPOR_MOUSE (97-392): 7.47e-41: 153: 17.26
+	Hs
		238353 JAK2_HUMAN (1-1132): 0: 1122: 100.00		EPOR_HUMAN (113-391): 7.72e-35: 136: 18.54
+	Mm
		960491 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL6RB_MOUSE (44-378): 1.67e-20: 96.1: 14.33
+	Hs
		238368 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL3RB_HUMAN (139-344): 4.28e-15: 79.5: 11.95
+	Hs
		238382 JAK2_HUMAN (1-1132): 0: 1122: 100.00		LEPR_HUMAN (38-387): 4.8e-12: 70.2: 15.12
+	Mm
		645934 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3B2_MOUSE (139-344): 3.69e-16: 82.6: 15.49
+	Hs
		238374 JAK2_HUMAN (1-1132): 0: 1122: 100.00		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86
+	Mm
		645936 JAK2_MOUSE (1-1129): 0: 1108: 93.89		IL3RB_MOUSE (139-344): 5.64e-15: 79.1: 16.44
+	Mm
		956337 JAK2_MOUSE (1-1129): 0: 1108: 93.89		I12R2_MOUSE (40-416): 1.57e-13: 74.5: 14.11
+	Mm
		817305 JAK2_MOUSE (1-1129): 0: 1108: 93.89		LEPR_MOUSE (195-382): 1.67e-10: 65.2: 17.95
+	Hs
		669159 TYK2_HUMAN (38-1132): 0: 870: 35.49		I13R1_HUMAN (27-366): 1.12e-52: 183: 19.83
+	Hs
		500950 TYK2_HUMAN (38-1132): 0: 870: 35.49		GHR_HUMAN (106-398): 9.47e-43: 160: 17.54
+	Hs
		669134 TYK2_HUMAN (38-1132): 0: 870: 35.49		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86