HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: ELP2 (Q6IA86)
Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1)
Gene: ELP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10954736
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0046425 - regulation of receptor signaling pathway via JAK-STAT
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1132 Hs			1 826
+	Hs
		669178 TYK2_HUMAN (38-1132): 0: 870: 35.49		ELP2_HUMAN (1-826): 1.47e-168: 510: 100.00
+	Hs
		616822 JAK1_HUMAN (830-1131): 8.62e-37: 153: 19.94		ELP2_HUMAN (1-826): 1.47e-168: 510: 100.00
+	Hs
		385003 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		ELP2_HUMAN (1-826): 1.47e-168: 510: 100.00
+	Hs
		433921 LYN_HUMAN (793-1132): 2.7e-93: 309: 29.91		PHIP_HUMAN (275-703): 1.75e-11: 70.3: 16.29
+	Hs
		384438 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		LIS1_HUMAN (384-752): 5.32e-38: 148: 11.54
+	Hs
		384733 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		TBL3_HUMAN (2-142): 4.37e-26: 116: 23.40
+	Hs
		384696 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		EMAL5_HUMAN (156-642): 6.71e-23: 107: 10.17
+	Hs
		254029 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		WDR1_HUMAN (7-254): 2.09e-15: 82.2: 14.29
+	Hs
		385218 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		GEMI5_HUMAN (652-825): 8.05e-15: 81.3: 10.57
+	Hs
		385480 NTRK1_HUMAN (526-808): 1.64e-20: 99.8: 24.59		TBL1R_HUMAN (382-696): 4.63e-11: 68: 17.80