HitPredict

Interactor 1: JAK2 (O60674)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17997974
Identification Methods	isothermal titration calorimetry
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SOCS_box
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1132 Hs			1 440
+	Mm
		222647 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS5_MOUSE (7-436): 1.54e-131: 391: 52.26
+	Hs
		238441 JAK2_HUMAN (1-1132): 0: 1122: 100.00		CISH_HUMAN (212-425): 3.46e-50: 172: 22.93
+	Hs
		238342 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SRC_HUMAN (135-389): 2.54e-45: 166: 12.55
+	Rn
		102468 JAK2_RAT (1-1131): 0: 1124: 94.70		G3V6B4_RAT (260-425): 1.48e-45: 158: 22.29
+	Hs
		181748 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29
+	Hs
		238330 JAK2_HUMAN (1-1132): 0: 1122: 100.00		FYN_HUMAN (202-387): 3.13e-42: 158: 17.10
+	Mm
		403446 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SRC_MOUSE (139-389): 6.82e-46: 168: 12.74
+	Mm
		980968 JAK2_MOUSE (1-1129): 0: 1108: 93.89		YES_MOUSE (151-429): 2.43e-45: 166: 15.39
+	Mm
		193352 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS1_MOUSE (260-425): 1.6e-45: 158: 22.29
+	Hs
		147366 JAK2_HUMAN (1-1132): 0: 1122: 100.00		SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09
+	Mm
		193387 JAK2_MOUSE (1-1129): 0: 1108: 93.89		SOCS3_MOUSE (250-422): 1.02e-38: 141: 20.09
+	Hs
		238350 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PLCG2_HUMAN (258-399): 1.57e-23: 105: 18.88
+	Hs
		238352 JAK2_HUMAN (1-1132): 0: 1122: 100.00		PLCG1_HUMAN (261-379): 1.1e-22: 103: 17.50
+	Hs
		238360 JAK2_HUMAN (1-1132): 0: 1122: 100.00		P85A_HUMAN (225-392): 2.48e-15: 80.3: 18.71
+	Mm
		643096 JAK2_MOUSE (1-1129): 0: 1108: 93.89		P85A_MOUSE (225-392): 2.99e-15: 79.9: 18.71
+	Hs
		146598 TYK2_HUMAN (38-1132): 0: 870: 35.49		SOCS2_HUMAN (234-425): 9.62e-47: 161: 25.85
+	Hs
		181802 TYK2_HUMAN (38-1132): 0: 870: 35.49		SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29
+	Hs
		412039 TYK2_HUMAN (38-1132): 0: 870: 35.49		FYN_HUMAN (202-387): 3.13e-42: 158: 17.10
+	Dm
		1099227 JAK_DROME (55-1125): 0: 627: 21.52		Q8INY1_DROME (137-434): 3.56e-58: 205: 42.28
+	Dm
		1099225 JAK_DROME (55-1125): 0: 627: 21.52		Q7JVF1_DROME (227-426): 1.35e-42: 154: 21.96