HitPredict

Interactor 1: CTND1 (O60716)
Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))
Gene: CTNND1

Interactor 2: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 12427869, 29207493, 12707304, 12640114, 7876318, 10409703, 33961781, 19711372, 21670201, 23180380, 22752307, 7651399, 25468996, 7542250, 9535896, 19114997, 25466890, 26707622, 34591612, 20371349 and 4 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, proximity labelling technology, x-ray crystallography, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Arm~CADH_Y-type_LIR
Common GO terms GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0007043 - cell-cell junction assembly
GO:0008013 - beta-catenin binding
GO:0016342 - catenin complex
and 7 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024