HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1239
+	Hs
		240096 HCN1_HUMAN (1-890): 0: 684: 100.00		MINK1_HUMAN (1-1239): 0: 1120: 59.29
+	Hs
		240248 HCN1_HUMAN (1-890): 0: 684: 100.00		TNIK_HUMAN (1-1239): 0: 1101: 60.56
+	Mm
		292120 HCN1_MOUSE (1-890): 0: 651: 90.35		TNIK_MOUSE (1-1239): 0: 1120: 62.43
+	Hs
		240047 HCN1_HUMAN (1-890): 0: 684: 100.00		MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29
+	Hs
		239795 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23
+	Hs
		240062 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK2_HUMAN (8-669): 2.09e-122: 399: 14.10
+	Hs
		240106 HCN1_HUMAN (1-890): 0: 684: 100.00		BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08
+	Rn
		812708 HCN1_RAT (1-890): 0: 657: 91.14		AKT1_RAT (2-354): 2.93e-122: 388: 20.82
+	At
		1105373 CNG13_ARATH (95-670): 4.53e-153: 468: 16.52		KIN10_ARATH (24-427): 9.81e-118: 377: 21.46
+	Mm
		292118 HCN1_MOUSE (1-890): 0: 651: 90.35		CTRO_MOUSE (304-593): 4.37e-10: 66.7: 14.56