HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: IGHG2 (P01859)
Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)
Gene: IGHG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 395
+	Hs
		239687 HCN1_HUMAN (1-890): 0: 684: 100.00		IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23
+	Hs
		239689 HCN1_HUMAN (1-890): 0: 684: 100.00		IGHG3_HUMAN (1-395): 6.18e-101: 308: 82.06
+	Hs
		239784 HCN1_HUMAN (1-890): 0: 684: 100.00		PTPRD_HUMAN (115-391): 6.43e-27: 115: 13.68
+	Hs
		239690 HCN1_HUMAN (1-890): 0: 684: 100.00		IGHM_HUMAN (1-383): 3.57e-24: 105: 20.75
+	Hs
		239737 HCN1_HUMAN (1-890): 0: 684: 100.00		PTPRF_HUMAN (2-337): 2.73e-17: 86.2: 11.91
+	Hs
		240114 HCN1_HUMAN (1-890): 0: 684: 100.00		TITIN_HUMAN (1-107): 2.98e-10: 64.7: 14.95
+	Hs
		239733 HCN1_HUMAN (1-890): 0: 684: 100.00		IGLC6_HUMAN (5-104): 7.15e-11: 60.5: 31.07
+	Hs
		239686 HCN1_HUMAN (1-890): 0: 684: 100.00		IGKC_HUMAN (225-317): 5.2e-10: 58.2: 29.47
+	Mm
		57583 KCNH2_MOUSE (3-883): 1.77e-167: 519: 18.01		TITIN_MOUSE (7-383): 3.34e-10: 64.3: 9.28