HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 983
+	Hs
		239877 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		240007 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		239798 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		239879 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		239878 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB1_HUMAN (28-983): 0: 1162: 55.69
+	Hs
		240236 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA6_HUMAN (3-980): 0: 1146: 60.16
+	Hs
		239876 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB3_HUMAN (24-983): 0: 1111: 56.17
+	Hs
		239956 HCN1_HUMAN (1-890): 0: 684: 100.00		TYRO3_HUMAN (289-882): 5.83e-141: 445: 23.41
+	Hs
		239707 HCN1_HUMAN (1-890): 0: 684: 100.00		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20
+	Hs
		412401 HCN2_HUMAN (3-812): 0: 576: 63.68		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20
+	Hs
		412422 HCN4_HUMAN (15-885): 3.07e-173: 536: 57.64		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20