HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030424 - axon GO:0030425 - dendrite GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 984
+	Hs
		239798 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB2_HUMAN (19-981): 0: 1198: 73.76
+	Hs
		240007 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA7_HUMAN (1-981): 0: 1151: 56.96
+	Hs
		239879 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA4_HUMAN (13-983): 0: 1150: 59.10
+	Hs
		239877 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA5_HUMAN (1-981): 0: 1143: 55.78
+	Hs
		239797 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA3_HUMAN (14-981): 0: 1131: 55.67
+	Hs
		239876 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHB3_HUMAN (16-979): 0: 1118: 70.56
+	Hs
		240236 HCN1_HUMAN (1-890): 0: 684: 100.00		EPHA6_HUMAN (1-982): 0: 1098: 52.04
+	Hs
		239956 HCN1_HUMAN (1-890): 0: 684: 100.00		TYRO3_HUMAN (131-964): 6.38e-160: 495: 19.28
+	Hs
		239707 HCN1_HUMAN (1-890): 0: 684: 100.00		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412401 HCN2_HUMAN (3-812): 0: 576: 63.68		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		412422 HCN4_HUMAN (15-885): 3.07e-173: 536: 57.64		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54