HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: MRCKG (Q6DT37)
Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 1551
+	Hs
		240310 HCN1_HUMAN (1-890): 0: 684: 100.00		MRCKB_HUMAN (2-1529): 0: 1261: 41.72
+	Hs
		240248 HCN1_HUMAN (1-890): 0: 684: 100.00		TNIK_HUMAN (47-1344): 0: 697: 15.83
+	Mm
		292120 HCN1_MOUSE (1-890): 0: 651: 90.35		TNIK_MOUSE (47-1344): 0: 693: 15.57
+	Hs
		240096 HCN1_HUMAN (1-890): 0: 684: 100.00		MINK1_HUMAN (47-1344): 0: 620: 15.64
+	Hs
		239795 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK3_HUMAN (17-767): 2.1e-154: 490: 16.23
+	Hs
		240226 HCN1_HUMAN (1-890): 0: 684: 100.00		MARK1_HUMAN (12-767): 3.15e-143: 461: 16.01
+	Mm
		292118 HCN1_MOUSE (1-890): 0: 651: 90.35		CTRO_MOUSE (11-890): 3.45e-115: 405: 25.00