HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: EVPL (Q92817)
Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)
Gene: EVPL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 2033
+	Hs
		239820 HCN1_HUMAN (1-890): 0: 684: 100.00		MYH10_HUMAN (1121-2019): 1.8e-30: 134: 8.80
+	Hs
		240116 HCN1_HUMAN (1-890): 0: 684: 100.00		MY18A_HUMAN (593-1184): 9.18e-23: 109: 15.26
+	Hs
		164538 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTN2_HUMAN (202-1664): 2.57e-18: 94.5: 11.80
+	Hs
		234162 HCN1_HUMAN (1-890): 0: 684: 100.00		PEPL_HUMAN (1-715): 5.64e-18: 93.4: 11.39
+	Hs
		240002 HCN1_HUMAN (1-890): 0: 684: 100.00		PLEC_HUMAN (1836-2029): 1.64e-13: 78.8: 34.02
+	Hs
		239819 HCN1_HUMAN (1-890): 0: 684: 100.00		MYH9_HUMAN (849-1682): 3.31e-12: 74.3: 20.96
+	Hs
		239884 HCN1_HUMAN (1-890): 0: 684: 100.00		EPIPL_HUMAN (1498-2013): 1.02e-11: 73.1: 17.14
+	Hs
		239952 HCN1_HUMAN (1-890): 0: 684: 100.00		DYST_HUMAN (654-1975): 1.61e-10: 69.1: 10.69
+	Hs
		239945 HCN1_HUMAN (1-890): 0: 684: 100.00		SPTB2_HUMAN (29-551): 3.68e-09: 64.5: 10.00
+	Mm
		292129 HCN1_MOUSE (1-890): 0: 651: 90.35		Q68FG2_MOUSE (202-1560): 7.93e-17: 89.9: 12.25
+	Mm
		292126 HCN1_MOUSE (1-890): 0: 651: 90.35		SPTB2_MOUSE (29-656): 2.79e-09: 64.9: 9.01