HitPredict

Interactor 1: HCN1 (O60741)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1)
Gene: HCN1

Interactor 2: PCLO (Q9Y6V0)
Protein piccolo (Aczonin)
Gene: PCLO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030424 - axon GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 890 Hs			1 5142
+	Mm
		292117 HCN1_MOUSE (1-890): 0: 651: 90.35		RP3A_MOUSE (4439-4991): 3.15e-76: 272: 16.75
+	Hs
		240099 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT2_HUMAN (4833-5138): 4.53e-61: 219: 17.42
+	Hs
		239777 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT1_HUMAN (4834-5138): 7.03e-58: 210: 15.86
+	Hs
		207681 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT7_HUMAN (4819-5140): 2.47e-46: 176: 16.87
+	Mm
		292111 HCN1_MOUSE (1-890): 0: 651: 90.35		BSN_MOUSE (192-4022): 7.05e-33: 144: 9.89
+	Hs
		129077 HCN1_HUMAN (1-890): 0: 684: 100.00		SYT5_HUMAN (4801-5109): 1.38e-17: 90.6: 15.97
+	Hs
		240276 HCN1_HUMAN (1-890): 0: 684: 100.00		RIMS2_HUMAN (4369-4855): 3.73e-16: 88.7: 14.14
+	Hs
		239757 HCN1_HUMAN (1-890): 0: 684: 100.00		KPCA_HUMAN (4696-4830): 1.81e-13: 79.3: 33.33
+	Hs
		239659 HCN1_HUMAN (1-890): 0: 684: 100.00		K0754_HUMAN (3838-4116): 3.5e-09: 66: 15.96
+	Hs
		135784 CNGA3_HUMAN (5-668): 1.46e-146: 451: 21.46		P3C2B_HUMAN (4650-4830): 1.25e-50: 202: 27.17
+	Mm
		57583 KCNH2_MOUSE (3-883): 1.77e-167: 519: 18.01		TITIN_MOUSE (3044-3937): 4.87e-09: 65.6: 9.81